Hiccups happen when the diaphragm, the muscle that controls our breathing, becomes irritated and start to spasm and contract uncontrollably. With each contraction, air is pulled into the lungs very quickly, passes through the voice box, and then the epiglottis closes behind the rush of air, shaking the vocal chords, causing the “hic” sound. The irritation can be caused by rapid eating, emotional stress and even some diseases. An international respiratory research group composed of members from Canada, France and Japan proposed that the hiccup is an evolutionary remnant of earlier amphibian respiration. Amphibians such as tadpoles gulp air and water across their gills via a rather simple motor reflex akin to mammalian hiccuping. The best cure? Breathing into a paper bag. This calms the diaphragm by increasing the amount of carbon dioxide in your bloodstream.